RIPK1 and liver mesenchymal hamartoma: Not only the change of histopathology indicating the initiation of necroptosis was a key role in the pathology of VMC; the experiment implicates that the inhibition of RIPK1 and RIPK3 resulted in a reduction of viral replication by around half (Kraft et al., 2021), suggesting that the activity of RIPK1/3 may also be crucial for CVB3 replication.