In addition, because RIP3 is an energy metabolism regulator switching TNF-induced apoptosis to necroptosis and the key determinant, the deficiency of RIP3 ameliorated myocardial necroptosis and heart failure by inhibiting cardiac remodeling (Cho et al., 2009; Sun et al., 2012; Zhao et al., 2012; Wu et al., 2013; Humphries et al., 2015; Zhang et al., 2016). Here, RIPK3 is linked to heart failure.