ACTB and neurodegenerative disease: Target prediction analyses revealed that these miRNAs regulate the brain-derived neurotrophic factor (BDNF) implicated in metabolic syndrome and neurodegenerative disease, but also the pathway of HIF1, including HIF1α, VEGFA, EGLN3, TFRC, and IGF. Some other targets are involved in neuronal compartment (ACTB, KALRN, MATN2, and RHOB), differentiation, morphogenesis and development.