SH2D3A and infection: However, the most recent major African variants, ORF8: 382 variant and NSP1: 500–532 variant, both of which affect around 5% of global infections and were found in Singapore and China, respectively, contain both ORF8 and NSP1 partial deletions, resulting in lower SARs infection with the CoV-2 virus [https://www.gisaid.org/hcov19-variants/; (68–70)].