ORF1a encodes 11 non-structural proteins (NSP1–11), whereas ORF1b encodes five non-structural proteins (NSP12–16), and ORF8, ORF7b, ORF7a, ORF6, and ORF3a genes encode six accessory proteins, the non-structural proteins being primarily functional proteins (enzymes) that act as a prerequisite for viral replication in tandem with methylation to provoke host responses during infection (5–11). Here, SH2D3A is linked to infection.