IGHE and Alzheimer disease: Herein, we described a case of an AD-HIES patient with chronic airway disease who benefited from omalizumab treatment.<h4>Case presentation</h4>A 28-year-old Chinese woman was admitted for recurrent cough for 7 years, markedly elevated serum IgE level, and recurrent pneumonia caused by multiple pathogens, such as <i>Pneumocystis jirovecii, Cytomegalovirus, Staphylococcus aureus, Aspergillus</i>, and <i>Mycobacterium tuberculosis</i>.