The results of this study suggest that haX-1 activates uveal melanoma cells through PI3K/AKT/eNOS by mediating mitochondrial dependent apoptotic pathways that trigger apoptosis, including loss of MMP, transfer of CyT C, and favorable modulation of Bax, Caspase 3, and Bcl2 as key events associated with apoptosis. This evidence concerns the gene HAX1 and uveal melanoma.