Next, we detected the effects of HLA-DQB1-AS1 on the proliferation and apoptosis in vitro and identified the proproliferative and antiapoptotic effects of HLA-DQB1-AS1 on hepatocellular carcinoma cells, demonstrating the tumor promoter role of HLA-DQB1-AS1. This evidence concerns the gene HLA-DQB1 and hepatocellular carcinoma.