As a follow-up to our recent study on transcriptional regulation of SARS-CoV-2 entry factors in lung8, herein, we studied the tissue distribution and localization of SARS-CoV-2 virus, viral replication, the transcripts of the host cell entry factors, ACE2 and TMPRSS2, and the transcriptional regulator of TMPRSS2, AR, in postmortem human organ systems using in situ and qRT-PCR approaches, and correlate those results to the histopathologic findings in COVID-19 patient autopsy cases. The gene discussed is TMPRSS2; the disease is COVID-19.