TMPRSS2 and COVID-19: To further investigate transcriptional inhibition of critical host factors in the treatment or prevention of COVID-19, we set out to characterize the distribution and localization of SARS-CoV-2 viral particles, viral replication, and the host entry factor receptor ACE2, priming protease TMPRSS2 and transcriptional regulator AR by RNA in situ hybridization (RNA-ISH), immunohistochemistry (IHC) and qRT-PCR in various pulmonary and nonpulmonary tissues obtained from a series of six clinical autopsies performed on patients who succumbed to COVID-19 disease.