Herein, we further characterized the tissue distribution of ACE2, TMPRSS2, and AR transcripts in multiorgan systems and found that the distribution of host entry factors, ACE2 and TMPRSS2, and regulator, AR, highly overlaps with the viral infection sites in pulmonary tissues and numerous nonpulmonary tissues, supporting the notion that targeting ACE2 and/or TMPRSS2 could be an effective treatment strategy to counter SARS-CoV-2 infection from a multiorgan perspective and inhibition of AR would be effective against SARS-CoV-2 infection8. The gene discussed is AR; the disease is viral infectious disease.