There are another six circulating proteins that have significant and replicated effects on severe COVID-19, although they are only replicated in one replication analysis (Supplementary Data 5): inter-alpha-trypsin inhibitor heavy chain H1 (OR: 1.08, 95% CI: 1.04–1.12), alpha-2-macroglobulin receptor-associated protein (OR: 1.14, 95% CI: 1.07–1.23), resistin (OR: 1.09, 95% CI: 1.07–1.11), reticulon-4 receptor (OR: 0.86, 95% CI: 0.79–0.93), C–C motif﻿ chemokine﻿ 23﻿ (OR: 0.88, 95% CI: 0.83–0.92), and collectin-10 (OR: 0.83, 95% CI: 0.76–0.901). This evidence concerns the gene RETN and COVID-19.