The patient tissue and corresponding organoid models were profiled for protein expression of relevant endometrial cancer markers: ER, PR, L1CAM, PTEN, ARID1A, and assigned to molecular subgroups according to the TCGA-like classification by evaluating IHC staining of P53 and MMR proteins (MSH6, MSH2, PMS2, and MLH1), and by Sanger sequencing of POLE41 (Fig. 2a). The gene discussed is MSH6; the disease is endometrial cancer.