In contrast, UNC5D, ST3GAL6, SCG3, and IGFBP1, which are negatively affected by noisy workplace environments, are potentially protective factors against coronary heart disease (UNC5D), type 2 diabetes (UNC5D), tinnitus (ST3GAL6, SCG3), and rheumatoid arthritis (IGFBP1). This evidence concerns the gene IGFBP1 and type 2 diabetes mellitus.