IL1B and acute kidney injury: For example, TMP [63], BBR [15, 90], Vin [68], protopine [92], evodiamine [91], harmine [70], neferine [103] and leonurine [72] can significantly reverse the massive release of TNF-α, IL-6, and IL-1β induced by AKI, among which proopioid protopine and evodiamine can also increase IL-10 level, regardless of LPS or I/R stimulation.