In NAFLD, oxidative stress induces the activation of numerous redox-sensitive transcription factors (nuclear factor kappa B (NF-κB), early growth response-1, and activator protein 1) and proinflammatory mediators (tumor necrosis factor α (TNF-α), interleukins (IL), etc.)leading to liver inflammation, fibrosis, and cell death [34–36]. The gene discussed is TNF; the disease is metabolic dysfunction-associated steatotic liver disease.