STX2 and hemolytic-uremic syndrome: Stx1 and Stx2 proteins bind to its receptor, globotriaosylceramide Gb3, localized on the host cell membrane, such as renal glomerular endothelial cells, resulting in cell death induction by inhibiting protein synthesis within host cells, which are closely associated with HUS development (Lingwood et al., 1987; Romer et al., 2007).