One study on the progression from acute kidney injury (AKI) to chronic kidney disease (CKD) in an ischemia–reperfusion-induced AKI model showed that the inhibition of CSF1R could significantly reduce the number of macrophages infiltrating the kidney and attenuate kidney injury and interstitial fibrosis by reducing the level of Ly6C + inflammatory macrophages (Deng et al., 2020). Here, CSF1R is linked to acute kidney injury.