The pendrin mutations included in Figure 1A are responsible for a variety of sensorineural hearing loss, including those found in patients with Pendred syndrome, as well as patients afflicted with non-syndromic hearing loss caused by enlarged vestibular aqueducts (EVA) (Dossena, et al., 2011; Roesch, et al., 2021). This evidence concerns the gene SLC26A4 and Pendred syndrome.