NOX4 and Obesity: NOX4 deletion accelerated hepatocyte proliferation after partial hepatectomy (Herranz-Itúrbide et al., 2021)—which is an essential component of the response—but also accelerated proliferation and migration in hepatocellular carcinoma (Crosas-Molist et al., 2014), suggesting that inhibiting NOX4 could exacerbate the progression of liver disease associated with obesity.