Unlike the other EGFR-TKIs, osimertinib (AZD9291), a third-generation, irreversible EGFR-TKI commonly used to treat EGFR-mutant lung cancer, is able to effectively penetrate the BBB and achieve therapeutic concentrations in brain tissue, making it an attractive option for gliomas with EGFR alterations [15, 16]. Here, EGFR is linked to central nervous system cancer.