Consistent with data reported in previous studies on the ACPA-positive RA form, our study identified significant correlations of ACPA presence with X-ray stage, RF, ESR, age of RA onset, VAS, BMI, and Gamma globulin level and is, thus, consistent with a more severe course of the disease in our cohort of RA patients [37, 43–45]. This evidence concerns the gene PRTN3 and rheumatoid arthritis.