ZEB is potent EMT inducer, which represses epithelial marks including E‐cadherin, ZO‐1, claudin‐1, desmoplakin, and is implicated in various type of cancer such as gastric cancer, leukemia, squamous cell carcinoma, liver cancer, colorectal cancer, and so on.82, 140, 150, 159, 275, 276, 277, 278. This evidence concerns the gene CDH1 and colorectal cancer.