A recent study using SH-SY5Y cells carrying the D620NVPS35 demonstrated that mutant VPS35 impairs the PINK1-PARKIN-mediated mitophagy through impaired PINK1 recruitment to mitochondria, suggesting a converging pathophysiological cascade among VPS35, PINK1, and PARKIN in PD (Ma et al., 2021). This evidence concerns the gene PRKN and Parkinson disease.