OTX2 and Anxiety: Blocking OTX2-PNN interaction or sequestering OTX2 in the CSF in adult mice can promote ocular dominance plasticity (Beurdeley et al., 2012; Bernard et al., 2016), while overexpression of OTX2 in the choroid plexus can rescue plasticity-dependent anxiety-like behavior deficits regulated in the mPFC (Vincent et al., 2021).