EGFR and cancer: The KEGG data of Figure 6E suggested that SHC1 influences tumor pathogenesis via “PI3K-Akt signaling pathway,” “Proteoglycans in cancer,” “Focal adhesion,” “ErbB signaling pathway” and “EGFR tyrosine kinase inhibitor resistance.” The GO enrichment analysis further showed that most of these genes were linked to the biological process and cellular component.