Notably, high SHC1 expression has negative effects on six cancers, including BRCA (DFS: total number = 54, HR = 1.48, Cox p = 0.003169), NSCLC (RFS: total number = 138, HR = 1.33, Cox p = 0.022761), SKCM(OS: total number = 38, HR = 6.33, Cox p = 0.001820), UVM (distant metastasis-free survival (DMFS): total number = 63, HR = 4.61, Cox p = 0.006817), LGG (OS: total number = 50, HR = 1.77, Cox p = 0.003169), and OV(progression-free survival (PFS): total number = 110, HR = 1.77, Cox p = 0.008976). The gene discussed is SHC1; the disease is non-small cell lung carcinoma.