HMGB2 and central nervous system cancer: Figure 15F showed that the model still maintained the excellent performance of discriminating prognosis in all clinical characteristics subgroups. Figures 15G–J showed the IHC staining images reflecting the protein expression levels of the four PR-DE-IRGs (HMGB2, CCNA2, CASP3, and APOBEC3C) in the model, respectively. We only observed higher expression of three genes (HMGB2, CCNA2, and CASP3) in the glioma tissues (Figures 15G–I), consistent with the conclusions from the previous analysis based on the TCGA cohort.