Using the regression coefficients for each of the above 6 prognostic genes, we constructed a prognostic model for DLBCL patients and calculated the risk score according to the following formula: risk score = (2.201 × GABRA3 expression level) + (−0.719 × HOXC8 expression level) + (−0.765 × RTN4R expression level) + (0.545 × CRLF1 expression level) + (−0.013 × BIRC3 expression level) + (−0.226 × REXO5 expression level). The gene discussed is BIRC3; the disease is diffuse large B-cell lymphoma.