Evidence from studies suggested that METTL14 regulates myelopoiesis and leukemogenesis through the SPI1-MET-TL14-MYB/MYC signaling axis, and the myeloid transcriptional regulator SPI1 negatively regulates METTL14 to induce the m6A modification of oncogenes MYB and MYC, thereby inhibiting AML cell differentiation and promoting cell self-renewal (Weng et al., 2018). This evidence concerns the gene METTL14 and acute myeloid leukemia.