The overexpression of m6A methyltransferase METTL14 and METTL3 in AML cells promoted the self-renewal of leukemic stem cells and the development and maintenance of AML (Barbieri et al., 2017; Vu et al., 2017; Weng et al., 2018). This evidence concerns the gene METTL3 and acute myeloid leukemia.