Low TMEM170B expression group usually have a history of alcohol abuse (p < 0.05), higher histologic grade (p < 0.05, G3 vs. G1) and more dead event (p < 0.001), but TMEM170B expression is not associated with sex, age, primary tumor (pT) stage, lymph node invasion, metastasis, and residual tumor (Figure 3C). Here, TMEM170B is linked to alcohol abuse.