In addition, the single-gene GSEA using the TCGA GC cohort identified epithelial mesenchymal transition (EMT) as the main hallmarks of the LPP high expression group (Supplementary Figure S3), and we discovered the DDX27 overexpression caused EMT activation which could be alleviated by LPP inhibition, while the LPP overexpression could partly recover DDX27-induced EMT impairment (Supplementary Figure S2G). The gene discussed is DDX27; the disease is gastric cancer.