Univariate analysis revealed that tumor size, invasion depth, lymph node metastasis, distant organic invasion, AJCC, and DDX27 expression all were associated with OS (p < 0.05, Table 2), and multivariate Cox regression analysis validated that a higher DDX27 expression was an independent risk factor for the GC patient prognosis and could predict patient’s shorter OS (p < 0.05, Table 3). The gene discussed is DDX27; the disease is neoplasm.