IRF1 and Parkinson disease: Based on these DEGs in endothelial cells, we established a PPI network and identified ten hub genes, including HSP90AA1, HSP90AB1, HSPA8, HSPA1A, DNAJB1, HSPA1B, HSPH1, IRF1, PTGES3, and DNAJA1. Among them, upregulated HSP90AB1 exerts complementary effects on protein misfolding during PD (Xie et al., 2016).