SARS-CoV-2 viral infection mediated RAS activation, via Ang-II and Angiotensin II type 1 receptor (AT1R), also triggers the TLR4/MyD88/NFκB pathway resulting in elevated pro-inflammatory cytokines including TNF-α, IL-1β, IL-6 and IL-8 (22). Here, AGTR1 is linked to viral infectious disease.