In addition to generalized exfoliative erythroderma, she presented, in the 1st day of life, with hepatosplenomegaly, enlarged lymph nodes, severe eosinophilia (10,335 cells/mm3), neutrophilia (5,625 cells/mm3), 2,925 lymphocytes/mm3, being CD3+ 684 cells/mm3, CD4+ 345 cells/mm3, CD8+ 8 cells/mm3, no naïve T cells, no CD127 expression, CD4+CD25+Foxp3+ 2.3%, CD19+ 641 cells/ mm3, IgG 468 mg/dL, IgM 45 mg/dL, IgE 3,310 UI/mL. This evidence concerns the gene CD4 and exfoliative dermatitis.