AKT1 and cancer: GSEA results showed that MAPK (nominal enrichment score (NES) = −0.44864, FDR = 0.005015), pathway in cancer (NES = −0.42543, FDR = 0.003), PI3K-Akt (NES = −0.47217, FDR = 0.001003), and Wnt pathways (NES = −0.49361, FDR = 0.004154) were distinctly activated in low TMB gastric cancer samples (Figure 3(b)).