Compared with the control group, the γH2A.X expression level of TRIP13 overexpression group was lower in KYSE150 cell and KYSE510 cell (Figures 5(b) and 5(c)), which demonstrated that when TRIP13 overexpressed, the cell apoptosis would decrease, and therefore, the NDP drug effect to ESCC would decrease. This evidence concerns the gene TRIP13 and esophageal squamous cell carcinoma.