Hence, due to previous reports regarding the theranostic role of PepA, our aim was to evaluate its effect upon T. cruzi experimental infection in vitro and in vivo. Besides PepA, two other sequences were assessed: one that maintains the “RS” region (PepB) and another that maintains all the amino acids in scrambled order to the original sequence (PepC). The gene discussed is CNDP2; the disease is infection.