LMLN and infection: It is noteworthy that Gp63/Leishmanolysin, a metalloproteinase containing a conserved zinc-binding/catalytic motif (HEXXH), is abundantly expressed on the surface of promastigotes and known to play significant roles in multiple steps of the infection comprising their entry into macrophages until their intralysosomal survival (Liu and Chang, 1992; Brittingham et al., 1999; Cerdà-Costa and Gomis-Rüth, 2014).