After that, an efficient 8-gene (RRP36, RPF1, GRWD1, FBL, BCCIP, TWISTNB, TBL3, and SKIV2L) T2D prediction model was obtained, whose AUC reached 0.84 and 0.67, respectively, in training set and test set. This evidence concerns the gene TBL3 and type 2 diabetes mellitus.