On this basis, we further identified 10 hub genes by the Cytohubba algorithm, namely, RRP36, RPF1, GRWD1, FBL, EXOSC5, BCCIP, UTP14A, TWISTNB, TBL3, and SKIV2L. One study showed that the methylation level of GRWD1 was associated with insulin resistance [35]. The gene discussed is EXOSC5; the disease is Insulin resistance.