TIMP1 and neoplasm: This can explain the increased TIMP-1 secretion and activity during Mg material degradation, while the MMP activity was relatively low at alkaline pHe In general, the acidity of the TME appears to be an important factor that promotes tumor invasion and metastases [[67], [68], [69]] and the pH neutralization with an oral administered alkaline agent was shown to inhibit cancer metastases [70,71].