Our protein chip analysis showed that compared with healthy women, PCOS patients had an inflammatory state with significantly increased serum levels of inflammatory cytokines CCL5/RANTES, CD40 ligand/TNFSF5, complement component C5/C5a, CXCL1/GROα, CXCL12/SDF-1, IL-1ra/IL-1F3, IL-8, IL-13, IL-16, IL-18/IL-1F4, MIF, and serpin E1/PAI-1. Here, IL1RN is linked to polycystic ovary syndrome.