IL-8, a proinflammatory chemokine secreted by microglia, astrocytes, and endothelial cells, is regarded as one of the most studied chemokines that plays a significant role in the development of atherosclerosis and future cardiovascular diseases [50], and elevated IL-8 is thought to be associated with IR in PCOS [51]. This evidence concerns the gene CXCL8 and atherosclerosis.