NR1H4 and irritable bowel syndrome: In vitro, FXR agonist INT-747 significantly downregulated expression of TNF-α, IL-17, and IFN-γ in peripheral blood monocytes, CD14+ monocytes, dendritic cells, and lamina propria monocytes of IBD patients; on the other hand, deoxycholic acid and GW4064 can inhibit the healing of intestinal epithelial damage by inducing the nuclear accumulation of FXR [75].