AKT1 and cancer: MiRNAs play an important role in regulating cancer cell stemness, tumor regeneration, metastasis and chemo-resistance during the development and progression of cancer (Sun et al., 2014; Rupaimoole and Slack, 2017) via targeting various signaling pathways including Wnt, Akt, Jak/Stat, et al. (Gomes et al., 2016; Matsui, 2016; Mihanfar et al., 2019).