SOCS2 and gastric cancer: miR-877-3p activated Jak2/Stat3 signaling through targeting SOCS2.  In order to determine the molecular mechanism(s) by which miR-877-3p promotes gastric cancer development and progression, RNA-seq was applied to the SGC7901 cells with or without stimulation with 5-FU or GM-CSF, deriving 176 downregulated genes by 5-FU treatment and 207 downregulated genes by GM-CSF treatment (Figures 5A,B).