MAPT and Alzheimer disease: Indeed, although it was postulated that the altered Aβ metabolism precedes the Tau-related pathology and neuronal degeneration, many reports showed that Tau hyperphosphorylation is a primary factor in AD independently on Aβ, and that the formation of amyloid plaques and neurofibrillary tangles may in fact act in parallel or in combination to contribute to the development of AD (Bloom, 2014).