At the moment of the clinical diagnosis, the brain of AD patients is mainly characterized by large extracellular deposits of aggregated Amyloid-β (Aβ) peptides, also called amyloid plaques, and by degenerating neurons containing neurofibrillary tangles (NFTs), which are mainly composed of the microtubule-associated protein Tau in a hyperphosphorylated form (Selkoe and Hardy, 2016; Trejo-Lopez et al., 2021). This evidence concerns the gene MAPT and Alzheimer disease.