APP and Alzheimer disease: In vivo studies have demonstrated that resveratrol is able to improve cognition and reduce amyloid plaque formation in Tg6799 mice (Chen et al., 2019), to inhibit microglial activation in APP/PS1 mice (Capiralla et al., 2012), and to decrease the amount of insoluble Aβ in the hippocampus of AD rats, with positive effects on BBB integrity (Zhao et al., 2015).