In this study, we showed that ARV-771 can downregulate multiple DUBs in HCC, including USP1, USP8, USP10, USP13, and USP18, which have been implicated in the tumorigenesis and progression by regulating certain substrates (Cai et al., 2017; Gao et al., 2020; Zhu et al., 2020; Liao et al., 2021b; Zhu et al., 2021). The gene discussed is USP8; the disease is hepatocellular carcinoma.