Treatment with polysaccharides isolated from Ganoderma lucidum was found to increase wound angiogenesis and to improves delayed wound healing in STZ-induced T1DM mice by partly lowering cutaneous MnSOD nitration, p66Shc, and reducing oxidative stress in mitochondria (Tie et al., 2012). This evidence concerns the gene SOD2 and type 1 diabetes mellitus.