HMGA2 and non-small cell lung carcinoma: In non-small cell lung cancer, lncRNA linc-SPRY3 could bind to IGF2BP3 (Insulin Like Growth Factor 2 MRNA Binding Protein 3), which leads to the destabilization of c-Myc and HMGA2, and improves the radiosensitivity of tumors (Brownmiller et al., 2020).