In esophageal cancer, lncRNA MAGI2-AS3 can recruit the histone methyltransferase EZH2 to the HOXB7 promoter region to initiate H3K27me3 and repress HOXB7 expression, resulting in enhanced tumor radiosensitivity (Cheng et al., 2020). The gene discussed is PRDM9; the disease is neoplasm.