H2BC21 and central nervous system cancer: In glioma, Linc-RA1 can combine with H2B to stabilize the level of H2B K120 monoubiquitination and inhibit the interaction between H2Bub1 and ubiquitin-specific protease 44 (USP44), thus regulating autophagy and enhanced radioresistance (Zheng et al., 2020).