There is no natural inducer of PAUF identified so far, but in a genomic network-based study (Kim et al., 2018), a few genes, such as AGR2 and POM121, were discovered to be closely and positively correlated with PAUF expression in cervical cancer settings; finding out whether inducers for these genes (Zhang et al., 2005) also induce PAUF expression and identifying natural PAUF inducers will remain clinically meaningful tasks for cancer prevention and treatment, particularly for those ovarian cancers that express relatively low level of PAUF. The gene discussed is POM121; the disease is ovarian carcinoma.