Park et al. (2019) demonstrated that the downregulation of GPx4 during myocardial infarction (MI) aggravates ferroptosis injury in myocardium. Guanine-rich RNA sequence binding factor 1 (Grsf1) is a member of the RNA-binding protein family that regulates RNA metabolism (Ufer, 2012). It is reported that Grsf1-mediated translational regulation of GPx4 expression is essential for embryonic brain development (Ufer et al., 2008). This evidence concerns the gene GPX4 and myocardial infarction.