In the ICI-NSCLC cohort (GSE136961), compared with the low TCR coexpression group, the high group shows a significantly lower expression of immune checkpoint molecules, such as HAVCR2, LAG3, IDO1, CTLA4, TIGIT,PD-1, and PDCD1LG2 (Figure 4B). This evidence concerns the gene TIGIT and non-small cell lung carcinoma.