Suppresses tumor growth; Prolongs survival; Increases the total number and activity of CTLs; Reduces the total number and activity of tumor-infiltrating PMN-MDSCs; Reduces the PMN-MDSC frequency and increases the CTL frequency in the spleen; Decreases the accumulation of myeloid-biased HSPCs in the spleen; Upregulates PD-L1 expression on tumoral and splenic PMN-MDSCs; IFN-γ+CD3+CD8+CTL↑; Arg-1↓; Stat3↓. The gene discussed is IFNG; the disease is neoplasm.