CHKA and hepatocellular carcinoma: In addition, CKI suppressed c-Myc expression by regulating the Wnt/β-catenin pathway in DEN-induced HCC rats, thereby inhibiting the production of key metabolites (citrate and lactate) and activity of enzymes (HK and PK) in the glycolytic process to regulate metabolic reprogramming in HCC (Wang K. X. et al., 2021b).