In vivo studies have revealed that direct targeted inhibition of VEGF by ginsenoside Rg3 in combination with TACE blocked angiogenesis and tumor growth, eventually reducing the tumor size and metastasis and prolonging OS in a buffalo rat orthotopic liver cancer model and rabbit liver VX2 carcinoma models (Yu et al., 2013; Zhou et al., 2014). Here, VEGFA is linked to neoplasm.