NCT03236636 was mainly focused on Chinese patients with HCC in terms of protocol design, 71 of 283 included patients with advanced HCC had positive CBS scores (AFP≥400 ng/ml, TNF-a<2.5 pg/ml and IFN-g ≥7.0 pg/ml), along with unfavorable prognostic factors such as BCLC C stage disease, HBV infection, and thrombocytopenia, which are more common in Chinese patient populations with HCC. This evidence concerns the gene IFNG and hepatocellular carcinoma.