CHKA and hepatocellular carcinoma: Ke-Xin Wang’s team and others used the propagation model of developed by Dijkstra to decode the effective network of key genotype-phenotypes for CKI treatment of HCC and found that CKI affect arginine and proline metabolism, aminoacyl-tRNA biosynthesis, D-glutamine and D-glutamate metabolism, alanine, aspartate and glutamate metabolism, and thiamine metabolism.