Another series of in vivo studies showed that ICT inhibits HCC development by modulating the tumor immunosuppressive microenvironment, downregulating tumor associated splenic extramedullary hematopoiesis (EMH), significantly reducing tumor and splenic myeloid-derived suppressor cell (MDSC) accumulation and activation, and increasing the number and killing capacity of CD8+T cells (Tao et al., 2021). Here, CD8A is linked to neoplasm.