This, in turn, inhibited IL-1β-induced cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expressions, thereby, indicating that ellagic acid could also modulate the oxidative stress (Lin et al., 2020), implicated in osteoarthritis (Sokolove and Lepus, 2013). Here, PTGS2 is linked to osteoarthritis.