Capsaicin, an agonist for the transient receptor potential cation channel subfamily V member 1 (TRPV1) is already being used as topical analgesic for osteoarthritis, although its injectable version, CNTX-4975 did not show promising anti-osteoarthritic activity in the clinical trial (Stevens et al., 2019). The gene discussed is TRPV1; the disease is osteoarthritis.