For example, Li et al. uncovered a SOX4/EZH2/METTL3 axis in TMZ-resistant glioblastoma (GBM), in which EZH2 regulates the METTL3 expression via an H3K27me3 modification-independent manner, and METTL3 leads to nonsense-mediated mRNA decay of EZH2 reversely (Li et al., 2021). Here, SOX4 is linked to glioblastoma.