VEGFA and malignant colon neoplasm: It was also shown to inhibit tumor angiogenesis, growth, and bone metastasis by downregulating the expression of vascular endothelial growth factor (VEGF), and it can inhibit the growth and migration of Human colon cancer cell (LoVo) colorectal cancer cells by regulating the Wnt/β-catenin signaling pathway (38, 39).